K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstro...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Dong, Y, Pike, A, Mackenzie, A, McClenaghan, C, Aryal, P, Dong, L, Quigley, A, Grieben, M, Goubin, S, Mukhopadhyay, S, Ruda, G, Clausen, M, Cao, L, Brennan, P, Burgess-Brown, N, Sansom, M, Tucker, S, Carpenter, E
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	American Association for the Advancement of Science 2015

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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