Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369...
Main Authors: | Justice, A, Karaderi, T, Highland, H, Mahajan, A, Gan, W, Karpe, F, Kitajima, H, McCarthy, M, Morris, A, Neville, C, Owen, K, Robertson, N, Southam, L, Lindgren, C |
---|---|
Format: | Journal article |
Published: |
Nature Publishing Group
2019
|
Similar Items
-
Rare and low-frequency coding variants alter human adult height
by: Marouli, E, et al.
Published: (2017) -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
by: Mahajan, A, et al.
Published: (2018) -
Sexual dimorphisms in genetic loci linked to body fat distribution.
by: Pulit, S, et al.
Published: (2017) -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
by: Justice, A, et al.
Published: (2017) -
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
by: Loh, NY, et al.
Published: (2020)