SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase and a nuclease that restricts HIV-1 in noncycling cells. Germ-line mutations in SAMHD1 have been described in patients with Aicardi-Goutières syndrome (AGS), a congenital autoimmune disease. In a previous longitudinal whole genome sequenci...

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Main Authors: Clifford, R, Louis, T, Robbe, P, Ackroyd, S, Burns, A, Timbs, A, Wright Colopy, G, Dreau, H, Sigaux, F, Judde, J, Rotger, M, Telenti, A, Lin, Y, Pasero, P, Maelfait, J, Titsias, M, Cohen, DR, Henderson, S, Ross, M, Bentley, D, Hillmen, P, Pettitt, A, Rehwinkel, J, Knight, S, Taylor, J
פורמט: Journal article
שפה:English
יצא לאור: American Society of Hematology 2014

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