18F-trifluoromethanesulfinate enables direct C–H 18F-trifluoromethylation of native aromatic residues in peptides

18F-trifluoromethanesulfinate enables direct C–H 18F-trifluoromethylation of native aromatic residues in peptides

18F-Labeling strategies for unmodified peptides with [18F]fluoride require 18F-prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here, we explore selective radical chemistry to target aromatic residues applying C–H 18F-trifluoromethylation. We report a one-step route t...

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Bibliografski detalji
Glavni autori: Kee, C, Tack, O, Guibbal, F, Wilson, T, Isenegger, P, Imiołek, M, Verhoog, S, Tilby, M, Boscutti, G, Ashworth, S, Chupin, J, Kashani, R, Poh, A, Sosabowski, J, Macholl, S, Plisson, C, Cornelissen, B, Willis, M, Passchier, J, Davis, B, Gouverneur, V
Format: Journal article
Jezik:English
Izdano: American Chemical Society 2020

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