A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2

The DNA-binding protein MeCP2 is reported to bind methylated cytosine in CG and CA motifs in genomic DNA, but it was recently proposed that arrays of tandemly repeated CA containing either methylated or hydroxymethylated cytosine are the primary targets for MeCP2 binding and function. Here we invest...

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Bibliographic Details
Main Authors: Chhatbar, K, Connelly, J, Webb, S, Kriaucionis, S, Bird, A
Format: Journal article
Language:English
Published: Life Science Alliance 2022