PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
Posttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797059368045248512 |
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| author | Yamane, K Tateishi, K Klose, R Fang, J Fabrizio, L Erdjument-Bromage, H Taylor-Papadimitriou, J Tempst, P Zhang, Y |
| author_facet | Yamane, K Tateishi, K Klose, R Fang, J Fabrizio, L Erdjument-Bromage, H Taylor-Papadimitriou, J Tempst, P Zhang, Y |
| author_sort | Yamane, K |
| collection | OXFORD |
| description | Posttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the identity of a histone demethylation system remained elusive until recently. The discovery of histone demethylase enzymes capable of directly removing methyl groups from modified lysine residues has demonstrated that histone methylation is a dynamic modification. The most extensive family of histone demethylase enzymes identified so far contains a JmjC domain and catalyzes demethylation through a hydroxylation reaction. Here, we identify PLU-1, a transcriptional repressor implicated in breast cancer, as a histone demethylase enzyme that has the ability to reverse the trimethyl H3K4 modification state. Furthermore, we reveal that PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1. |
| first_indexed | 2024-03-06T20:03:13Z |
| format | Journal article |
| id | oxford-uuid:28090497-93d2-44b3-a0f7-c7233f307fbb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:03:13Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:28090497-93d2-44b3-a0f7-c7233f307fbb2022-03-26T12:10:27ZPLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:28090497-93d2-44b3-a0f7-c7233f307fbbEnglishSymplectic Elements at Oxford2007Yamane, KTateishi, KKlose, RFang, JFabrizio, LErdjument-Bromage, HTaylor-Papadimitriou, JTempst, PZhang, YPosttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the identity of a histone demethylation system remained elusive until recently. The discovery of histone demethylase enzymes capable of directly removing methyl groups from modified lysine residues has demonstrated that histone methylation is a dynamic modification. The most extensive family of histone demethylase enzymes identified so far contains a JmjC domain and catalyzes demethylation through a hydroxylation reaction. Here, we identify PLU-1, a transcriptional repressor implicated in breast cancer, as a histone demethylase enzyme that has the ability to reverse the trimethyl H3K4 modification state. Furthermore, we reveal that PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1. |
| spellingShingle | Yamane, K Tateishi, K Klose, R Fang, J Fabrizio, L Erdjument-Bromage, H Taylor-Papadimitriou, J Tempst, P Zhang, Y PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title | PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title_full | PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title_fullStr | PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title_full_unstemmed | PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title_short | PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
| title_sort | plu 1 is an h3k4 demethylase involved in transcriptional repression and breast cancer cell proliferation |
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