Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS-CoV-2 in mice

SARS-CoV-2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID-19). The type I interferon (IFN) pathway is of particular importance for anti-viral defense and recent studies identified that type I IFNs drive early inflammatory responses to SARS-CoV-2...

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Bibliographic Details
Main Authors: Ogger, PP, Garcia Martín, M, Michalaki, C, Zhou, J, Brown, JC, Du, Y, Miah, KM, Habib, O, Hyde, SC, Gill, DR, Barclay, WS, Johansson, C
Format: Journal article
Language:English
Published: Wiley 2022