Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms...

Full description

Bibliographic Details
Main Authors: Tyson, JJ, Novák, B
Format: Journal article
Language:English
Published: BioMed Central 2015