Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.

Staphylococcus aureus and Streptococcus pyogenes, two important human pathogens, target host fibronectin (Fn) in their adhesion to and invasion of host cells. Fibronectin-binding proteins (FnBPs), anchored in the bacterial cell wall, have multiple Fn-binding repeats in an unfolded region of the prot...

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Bibliographic Details
Main Authors: Schwarz-Linek, U, Werner, J, Pickford, A, Gurusiddappa, S, Kim, J, Pilka, E, Briggs, J, Gough, T, Höök, M, Campbell, I, Potts, JR
Format: Journal article
Language:English
Published: 2003