RNA polymerase pausing during initial transcription

RNA polymerase pausing during initial transcription

In bacteria, RNA polymerase (RNAP) initiates transcription by synthesizing short transcripts that are either released or extended to allow RNAP to escape from the promoter. The mechanism of initial transcription is unclear due to the presence of transient intermediates and molecular heterogeneity. H...

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Bibliografiske detaljer
Main Authors:	Duchi, D, Bauer, D, Fernandez, L, Evans, G, Robb, N, Hwang, L, Gryte, K, Tomescu, A, Zawadzki, P, Morichaud, Z, Brodolin, K, Kapanidis, A
Format:	Journal article
Sprog:	English
Udgivet:	Cell Press 2016

Lignende værker

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The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: Implications for transcription start-site selection
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The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.
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Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria
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Udgivet: (2018-04-01)

Single-Molecule Studies of Transcription Initiation using a Vesicle Approach
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Udgivet: (2012)

CDK9-dependent RNA polymerase II pausing controls transcription initiation
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Real-time transcription initiation by E. coli RNA polymerase in vitro and in vivo
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Udgivet: (2015)

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Udgivet: (2022-01-01)

Sensing DNA opening in transcription using quenchable Forster resonance energy transfer.
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Udgivet: (2010)

A pause site for RNA polymerase II is associated with termination of transcription.
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Udgivet: (1991)

Role of R-loops in pause-dependent transcriptional termination of RNA polymerase II
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Udgivet: (2012)

Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
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Udgivet: (2018-07-01)

Pause sites promote transcriptional termination of mammalian RNA polymerase II.
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Udgivet: (2006)

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Udgivet: (2013)

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Udgivet: (2014)

Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism.
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Udgivet: (2006)

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Udgivet: (2019-06-01)

A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis
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The pause-initiation limit restricts transcription activation in human cells
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Udgivet: (2019-08-01)

Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing
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Udgivet: (2019-01-01)

Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.
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Udgivet: (1993)

RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts.
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Udgivet: (2012-01-01)

Improved temporal resolution and linked hidden Markov modeling for switchable single-molecule FRET.
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Udgivet: (2011)

Transcription Pause and Escape in Neurodevelopmental Disorders
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Tyrosine 1-phosphorylated RNA polymerase II transcribes PROMPTs to facilitate proximal promoter pausing and induce global transcriptional repression in response to DNA damage
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Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability.
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Udgivet: (2011-05-01)

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
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Udgivet: (2023)

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
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Udgivet: (2023)

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Udgivet: (1992)

Structures of co-transcriptional RNA capping enzymes on paused transcription complex
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Definition of transcriptional pause elements in fission yeast.
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Udgivet: (1999)

c-Myc regulates transcriptional pause release
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Udgivet: (2012)