Molecular basis of class A β-lactamase inhibition by relebactam

Molecular basis of class A β-lactamase inhibition by relebactam

β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase (SBL) producers, especially strains carrying the widely disseminated class A enzymes, are required. Relebactam, a diazabicyclooctane (DBO)...

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Bibliographic Details
Main Authors:	Tooke, C, Hinchlifee, P, Lang, P, Mulholland, A, Brem, J, Schofield, C, Spencer, J
Format:	Journal article
Published:	American Society for Microbiology 2019

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