syn-β-Hydroxyallylic silanes from terminal epoxide α-lithiation-silylation and alkenylation: application to the tetrahydrofuran portion of the lytophilippines.
Lithiation-in situ silylation of terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with phenyldimethyl(or diethyl)silyl chloride provides a direct process for the synthesis of trans-α,β-epoxysilanes, which undergo α-ring opening with alkenylcoppers to give syn-β-hydroxyall...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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