Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package

A description of the materials and methods is included within the TEP datasheet. This work provides the early tools to develop substrate reduction inhibitors for a genetic childhood seizure disorder, with the hypothesis to target the enzyme (AASS) upstream of the defective gene (ALDH7A1) in the huma...

Deskribapen osoa

Xehetasun bibliografikoak
Beste egile batzuk:	Kopec, J
Formatua:	Dataset
Argitaratua:	University of Oxford 2018
Gaiak:	Structural Genomics Chemical Biology Drug Discovery

Antzeko izenburuak

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
nork: Kopec, J
Argitaratua: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
nork: Yue, W
Argitaratua: (2018)

Human RECQL5 Helicase; A Target Enabling Package
nork: Gileadi, O
Argitaratua: (2018)

Human RECQL5 Helicase; A Target Enabling Package
nork: Newman, J
Argitaratua: (2018)

Human RECQL5 Helicase; A Target Enabling Package
nork: Newman, J
Argitaratua: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
nork: Carpenter, E
Argitaratua: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
nork: Chu, A
Argitaratua: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
nork: Dong, Y
Argitaratua: (2018)

Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
nork: Dixon-Clarke, S
Argitaratua: (2018)

Cyclin-Dependent Kinase 12 (CDK12), human kinase domain; A Target Enabling Package
Argitaratua: (2018)

LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
nork: Mathea, S
Argitaratua: (2018)

LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
nork: Bullock, A
Argitaratua: (2018)

Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package
Argitaratua: (2018)

LIM Domain Kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
nork: Mathea, S
Argitaratua: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
nork: Bullock, A
Argitaratua: (2018)

With no lysine kinase 3 (WNK3); A Target Enabling Package
nork: Pinkas, D
Argitaratua: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
nork: Pinkas, D
Argitaratua: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
nork: Cox, O
Argitaratua: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
nork: Cox, O
Argitaratua: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
nork: Brennan, P
Argitaratua: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
nork: Brennan, P
Argitaratua: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
nork: Brennan, P
Argitaratua: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
nork: Savitsky, P
Argitaratua: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
nork: Brennan, P
Argitaratua: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
nork: Brennan, P
Argitaratua: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
nork: Savitsky, P
Argitaratua: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
nork: Newman, J
Argitaratua: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
nork: Gileadi, O
Argitaratua: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
nork: Newman, J
Argitaratua: (2018)

The Effects of a Single Oral Dose of Pyridoxine on Alpha-Aminoadipic Semialdehyde, Piperideine-6-Carboxylate, Pipecolic Acid, and Alpha-Aminoadipic Acid Levels in Pyridoxine-Dependent Epilepsy
nork: Junjuan Wang, et al.
Argitaratua: (2019-08-01)

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
nork: Wolfreys, F
Argitaratua: (2017)

Application of Fragment-Based Drug Discovery to Versatile Targets
nork: Qingxin Li
Argitaratua: (2020-08-01)

Analysis of multiple compound–protein interactions reveals novel bioactive molecules
nork: Hiroaki Yabuuchi, et al.
Argitaratua: (2011-03-01)

Dietary management for pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency, a follow‐on from the international consortium guidelines
nork: Marjorie Dixon, et al.
Argitaratua: (2024-05-01)

Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025
nork: Michele Cianci, et al.
Argitaratua: (2022-04-01)

Connecting genetics and gene expression data for target prioritisation and drug repositioning
nork: Enrico Ferrero, et al.
Argitaratua: (2018-05-01)

Targeting the ubiquitin system by fragment-based drug discovery
nork: Cassandra Kennedy, et al.
Argitaratua: (2022-09-01)

Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
nork: Annie N. Cowell, et al.
Argitaratua: (2019-10-01)

Genetic Architecture of Plasma Alpha‐Aminoadipic Acid Reveals a Relationship With High‐Density Lipoprotein Cholesterol
nork: Mingjian Shi, et al.
Argitaratua: (2022-06-01)

AN EFFECTIVE SUBSTITUTE FOR ALPHA-AMINOADIPIC ACID IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
nork: Baldwin, J, et al.
Argitaratua: (1987)