Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Lipoproteins serve essential roles in the bacterial cell envelope. The posttranslational modification pathway leading to lipoprotein synthesis involves three enzymes. All are potential targets for the development of new antibiotics. Here we report the crystal structure of the last enzyme in the path...

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Hlavní autoři: Wiktor, M, Weichert, D, Howe, N, Huang, C, Olieric, V, Boland, C, Bailey, J, Vogeley, L, Stansfeld, P, Buddelmeijer, N, Wang, M, Caffrey, M
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2017

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