Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Lipoproteins serve essential roles in the bacterial cell envelope. The posttranslational modification pathway leading to lipoprotein synthesis involves three enzymes. All are potential targets for the development of new antibiotics. Here we report the crystal structure of the last enzyme in the path...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Wiktor, M, Weichert, D, Howe, N, Huang, C, Olieric, V, Boland, C, Bailey, J, Vogeley, L, Stansfeld, P, Buddelmeijer, N, Wang, M, Caffrey, M
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Nature Publishing Group 2017

Míreanna comhchosúla

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis
de réir: Maciej Wiktor, et al.
Foilsithe / Cruthaithe: (2017-07-01)

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin
de réir: Stansfeld, P, et al.
Foilsithe / Cruthaithe: (2016)

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
de réir: Samir Olatunji, et al.
Foilsithe / Cruthaithe: (2021-07-01)

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis
de réir: El Ghachi, M, et al.
Foilsithe / Cruthaithe: (2018)

Bacterial Lipoprotein Posttranslational Modifications. New Insights and Opportunities for Antibiotic and Vaccine Development
de réir: Luke Smithers, et al.
Foilsithe / Cruthaithe: (2021-12-01)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
de réir: Alice Ossoli, et al.
Foilsithe / Cruthaithe: (2016-06-01)

In vitro transformation of apoA-I-containing lipoprotein subpopulations: role of lecithin:cholesterol acyltransferase and apoB-containing lipoproteins.
de réir: M C Cheung, et al.
Foilsithe / Cruthaithe: (1989-04-01)

Lecithin:cholesterol acyltransferase-induced transformation of HepG2 lipoproteins.
de réir: M R McCall, et al.
Foilsithe / Cruthaithe: (1989-10-01)

Remodelling of reconstituted high density lipoproteins by lecithin: cholesterol acyltransferase
de réir: H Q Liang, et al.
Foilsithe / Cruthaithe: (1996-09-01)

A study of the interaction of lecithin: cholesterol acyltransferase with subfractions of high density lipoproteins.
de réir: M Jahani, et al.
Foilsithe / Cruthaithe: (1981-09-01)

Growth and acyltransferase activity of rabbit mammary gland during pregnancy and lactation
de réir: M Caffrey, et al.
Foilsithe / Cruthaithe: (1977-01-01)

Effect of lecithin:cholesterol acyltransferase on distribution of apolipoprotein A-IV among lipoproteins of human plasma.
de réir: C L Bisgaier, et al.
Foilsithe / Cruthaithe: (1987-06-01)

Role of plasma lecithin:cholesterol acyltransferase in the metabolism of high density lipoproteins
de réir: J.A. Glomset, et al.
Foilsithe / Cruthaithe: (1966-09-01)

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins.
de réir: M C Cheung, et al.
Foilsithe / Cruthaithe: (1990-05-01)

Distribution of apolipoprotein A-IV between the lipoprotein and the lipoprotein-free fractions of rat plasma: possible role of lecithin:cholesterol acyltransferase.
de réir: J G DeLamatre, et al.
Foilsithe / Cruthaithe: (1983-12-01)

Abnormalities in lipoproteins of d < 1.006 g/ml in familial lecithin:cholesterol acyltransferase deficiency
de réir: J A Glomset, et al.
Foilsithe / Cruthaithe: (1980-11-01)

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis
de réir: Meriem El Ghachi, et al.
Foilsithe / Cruthaithe: (2018-03-01)

Acetylation of Surface Carbohydrates in Bacterial Pathogens Requires Coordinated Action of a Two-Domain Membrane-Bound Acyltransferase
de réir: Caroline R. Pearson, et al.
Foilsithe / Cruthaithe: (2020-08-01)

Se-MAG Is a Convenient Additive for Experimental Phasing and Structure Determination of Membrane Proteins Crystallised by the Lipid Cubic Phase (In Meso) Method
de réir: Coilín Boland, et al.
Foilsithe / Cruthaithe: (2023-09-01)

A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin: cholesterol acyltransferase deficiency.
de réir: C Chen, et al.
Foilsithe / Cruthaithe: (1984-03-01)

Thematic Review Series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis*
de réir: Yong-Mei Zhang, et al.
Foilsithe / Cruthaithe: (2008-09-01)

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport
de réir: Richard T. George, et al.
Foilsithe / Cruthaithe: (2021-07-01)

Cholesterol efflux by acute-phase high density lipoprotein: role of lecithin:cholesterol acyltransferase1
de réir: Weerapan Khovidhunkit, et al.
Foilsithe / Cruthaithe: (2001-06-01)

Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy.
de réir: Y I Parmar, et al.
Foilsithe / Cruthaithe: (1989-05-01)

High density lipoprotein subpopulations from galactosamine-treated rats and their transformation by lecithin:cholesterol acyltransferase
de réir: JE Matsuura, et al.
Foilsithe / Cruthaithe: (1991-04-01)

Role of lecithin:cholesterol acyltransferase and apolipoprotein A-I in cholesterol esterification in lipoprotein-X in vitro
de réir: K O, et al.
Foilsithe / Cruthaithe: (1995-11-01)

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
de réir: Samir Olatunji, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Recombinant lecithin:cholesterol acyltransferase containing a Thr123–>Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein.
de réir: K O, et al.
Foilsithe / Cruthaithe: (1993-01-01)

Hyperlipoproteinemia in Nagase analbuminemic rats: effects of pravastatin on plasma (apo)lipoproteins and lecithin:cholesterol acyltransferase activity.
de réir: A Van Tol, et al.
Foilsithe / Cruthaithe: (1991-11-01)

Properties of acyl-coenzyme A:1-acylglycerophosphate acyltransferase and lipases in porcine erythrocyte membranes.
de réir: M Mizuno, et al.
Foilsithe / Cruthaithe: (1984-08-01)

The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin:cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts.
de réir: A K Soutar, et al.
Foilsithe / Cruthaithe: (1982-03-01)

Hedgehog Acyltransferase: Structure, Function and Inhibition
de réir: Coupland, C
Foilsithe / Cruthaithe: (2022)

Insights into membrane protein-lipid interactions from free energy calculations
de réir: Corey, R, et al.
Foilsithe / Cruthaithe: (2019)

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1
de réir: Mohamad Navab, et al.
Foilsithe / Cruthaithe: (2000-09-01)

High density lipoproteins with differing apolipoproteins: relationships to postprandial lipemia, cholesteryl ester transfer protein, and activities of lipoprotein lipase, hepatic lipase, and lecithin: cholesterol acyltransferase.
de réir: H O Mowri, et al.
Foilsithe / Cruthaithe: (1994-02-01)

Glycerophosphate/Acylglycerophosphate Acyltransferases
de réir: Atsushi Yamashita, et al.
Foilsithe / Cruthaithe: (2014-11-01)

Molecular species of phosphatidylcholine in abetalipoproteinemia: effect of lecithin:cholesterol acyltransferase and lysolecithin acyltransferase.
de réir: B Banerji, et al.
Foilsithe / Cruthaithe: (1989-12-01)

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
de réir: Mohamad Navab, et al.
Foilsithe / Cruthaithe: (2000-09-01)

Human Lipoproteins at Model Cell Membranes: Effect of Lipoprotein Class on Lipid Exchange
de réir: K. L. Browning, et al.
Foilsithe / Cruthaithe: (2017-08-01)

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.
de réir: A.K. Okwu, et al.
Foilsithe / Cruthaithe: (1994-04-01)