Mechanism of action of nikkomycin and the peptide transport system of Candida albicans.
Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki = 0.16 microM (0.1 microgram ml-1)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1985
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