A protein biosensor that relies on bending of single DNA molecules.

A "bendy" protein sensor: A DNA-based sensor that uses folded DNA (through DNA kinks) and protein-induced bending to detect DNA-binding proteins is presented. Single-molecule sensing of a transcriptional activator (catabolite activator protein, CAP, which bends its DNA site by 80°) is demo...

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Hlavní autoři: Crawford, R, Kelly, D, Kapanidis, A
Médium: Journal article
Jazyk:English
Vydáno: 2012