HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.

HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.

HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia...

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Bibliographic Details
Main Authors: Kløverpris, H, Stryhn, A, Harndahl, M, Payne, R, Towers, G, Chen, F, Riddell, L, Walker, B, Ndung'u, T, Leslie, A, Buus, S, Goulder, P
Format: Journal article
Language:English
Published: 2013

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