HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.
HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1826264497839407104 |
|---|---|
| author | Kløverpris, H Stryhn, A Harndahl, M Payne, R Towers, G Chen, F Riddell, L Walker, B Ndung'u, T Leslie, A Buus, S Goulder, P |
| author_facet | Kløverpris, H Stryhn, A Harndahl, M Payne, R Towers, G Chen, F Riddell, L Walker, B Ndung'u, T Leslie, A Buus, S Goulder, P |
| author_sort | Kløverpris, H |
| collection | OXFORD |
| description | HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs. |
| first_indexed | 2024-03-06T20:08:46Z |
| format | Journal article |
| id | oxford-uuid:29d25691-1c08-4586-b11c-ed4456a6d8a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:08:46Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:29d25691-1c08-4586-b11c-ed4456a6d8a52022-03-26T12:21:27ZHLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:29d25691-1c08-4586-b11c-ed4456a6d8a5EnglishSymplectic Elements at Oxford2013Kløverpris, HStryhn, AHarndahl, MPayne, RTowers, GChen, FRiddell, LWalker, BNdung'u, TLeslie, ABuus, SGoulder, PHLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs. |
| spellingShingle | Kløverpris, H Stryhn, A Harndahl, M Payne, R Towers, G Chen, F Riddell, L Walker, B Ndung'u, T Leslie, A Buus, S Goulder, P HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title | HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title_full | HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title_fullStr | HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title_full_unstemmed | HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title_short | HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. |
| title_sort | hla specific intracellular epitope processing shapes an immunodominance pattern for hla b 57 that is distinct from hla b 58 01 |
| work_keys_str_mv | AT kløverprish hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT stryhna hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT harndahlm hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT payner hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT towersg hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT chenf hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT riddelll hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT walkerb hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT ndungut hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT lesliea hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT buuss hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 AT goulderp hlaspecificintracellularepitopeprocessingshapesanimmunodominancepatternforhlab57thatisdistinctfromhlab5801 |