53BP1‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling

DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a relatively greater impact on overall genome stability. The ribosomal RNA gene repeats (rDNA) are emerging fragile sites. Recent progress in understanding how the rDNA damage...

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Bibliographic Details
Main Authors: Tsaridou, S, Velimezi, G, Willenbrock, F, Chatzifrangkeskou, M, Elsayed, W, Panagopoulos, A, Karamitros, D, Gorgoulis, V, Lygerou, Z, Roukos, V, O'Neill, E, Pefani, DE
Format: Journal article
Language:English
Published: Springer 2022