Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We in...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Wright, PT, Bhogal, NK, Diakonov, I, Pannell, LMK, Perera, RK, Bork, NI, Schobesberger, S, Lucarelli, C, Faggian, G, Alvarez-Laviada, A, Zaccolo, M, Kamp, TJ, Balijepalli, RC, Lyon, AR, Harding, SE, Nikolaev, VO, Gorelik, J
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Elsevier 2018

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