Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia.
The tumour suppressor gene, p53, plays an important role in tumour development. Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that st...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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