Isolation of a small molecule inhibitor of DNA base excision repair.

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP endonuclease in human cells (APE1, also termed HAP1 and Ref-...

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Bibliografiska uppgifter
Huvudupphovsmän:	Madhusudan, S, Smart, F, Shrimpton, P, Parsons, J, Gardiner, L, Houlbrook, S, Talbot, D, Hammonds, T, Freemont, P, Sternberg, M, Dianov, G, Hickson, I
Materialtyp:	Journal article
Språk:	English
Publicerad:	2005

Isolation of a small molecule inhibitor of DNA base excision repair.

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