ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

Cardiomyopathy caused by lamin A/C gene mutations (LMNA cardiomyopathy) is characterized by increased myocardial fibrosis, which impairs left ventricular relaxation and predisposes to heart failure, and cardiac conduction abnormalities. While we previously discovered abnormally elevated extracellula...

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Dades bibliogràfiques
Autors principals: Chatzifrangkeskou, M, Le Dour, C, Wu, W, Morrow, J, Joseph, L, Beuvin, M, Sera, F, Homma, S, Vignier, N, Mougenot, N, Bonne, G, Lipson, K, Worman, H, Muchir, A
Format: Journal article
Idioma:English
Publicat: Oxford University Press 2017

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