Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

Inhibition by intracellular H(+) (pH gating) and activation by phosphoinositides such as PIP(2) (PIP(2)-gating) are key regulatory mechanisms in the physiology of inwardly-rectifying potassium (Kir) channels. Our recent findings suggest that PIP(2) gating and pH gating are controlled by an intra-sub...

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Bibliografische gegevens
Hoofdauteurs: Rapedius, M, Paynter, J, Fowler, P, Shang, L, Sansom, MS, Tucker, S, Baukrowitz, T
Formaat: Journal article
Taal:English
Gepubliceerd in: 2007