Hyperpolarized 13c magnetic resonance spectroscopy identifies changes to myocardial metabolic fluxes in a rat model of doxorubicin-induced cardiotoxicity

Hyperpolarized 13c magnetic resonance spectroscopy identifies changes to myocardial metabolic fluxes in a rat model of doxorubicin-induced cardiotoxicity

Xehetasun bibliografikoak
Egile Nagusiak:	Timm, KN, Miller, JJ, Ball, V, Henry, JA, Savic, D, Dodd, MS, Tyler, DJ
Formatua:	Conference item
Hizkuntza:	English
Argitaratua:	BMJ 2018

Antzeko izenburuak

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
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The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity
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Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
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Hyperpolarized ketone body metabolism in the rat heart
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L-Carnitine stimulates in vivo carbohydrate metabolism in the Type 1 diabetic heart as demonstrated by hyperpolarized MRI
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The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.
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Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS
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Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR
nork: Marco-Rius, I, et al.
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Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.
nork: Ball, DR, et al.
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Multi-parametric MRI evaluation of doxorubicin-induced cardiotoxicity in a canine model
nork: Hu, C, et al.
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Hyperpolarized magnetic resonance shows that the antiischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved postischemic function in the diabetic heart
nork: Savic, D, et al.
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Proof-of-principle demonstration of direct metabolic imaging following myocardial infarction using hyperpolarized 13C CMR
nork: Apps, A, et al.
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Investigating the functional and metabolic role of carnitine in the diabetic heart using hyperpolarized MRI
nork: Savic, D
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An Engineered Bivalent Neuregulin Protects Against Doxorubicin-Induced Cardiotoxicity With Reduced Proneoplastic Potential
nork: Jay, Steven M., et al.
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Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain
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Mollification of doxorubicin (DOX)-mediated cardiotoxicity using conjugated chitosan nanoparticles with supplementation of propionic acid
nork: Siva, Durairaj, et al.
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Linking diabetic cardiovascular disease with non-alcoholic fatty liver disease through L-carnitine: A hyperpolarized MRS study
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Rapid, B1-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux
nork: Miller, JJ, et al.
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Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 t with 3d spectral-spatial EPI.
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Susceptibility‐induced distortion correction in hyperpolarized echo planar imaging
nork: Miller, JJ, et al.
Argitaratua: (2017)

Application of hyperpolarized magnetic resonance in the study of cardiac metabolism
nork: Tyler, D, et al.
Argitaratua: (2008)

The cardiotoxicity of antimalarials
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A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
nork: Tyler, D, et al.
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In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
nork: Dodd, M, et al.
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Hyperpolarized 13 C and 31 P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment
nork: Lewis, AJM, et al.
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Non-invasive in vivo assessment of cardiac metabolism in the healthy and diabetic human heart using hyperpolarized 13C MRI
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Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol
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Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
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Clinical cardiovascular applications of hyperpolarized magnetic resonance
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Cardiotoxicity of antimalarial drugs.
nork: White, N
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Determination of cardiac metabolism in vivo with hyperpolarized carbon-13 magnetic resonance
nork: Schroeder, M, et al.
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Use of Hyperpolarized Magnetic Resonance for Non-Invasive Observation of Metabolic Regulation
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IMPAIRED IN VIVO MITOCHONDRIAL KREBS CYCLE ACTIVITY FOLLOWING MYOCARDIAL INFARCTION ASSESSED USING HYPERPOLARIZED MAGNETIC RESONANCE SPECTROSCOPY
nork: Dodd, M, et al.
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Cardiovascular Applications of Hyperpolarized MRI.
nork: Tyler, D
Argitaratua: (2011)

The development and application of new hyperpolarized magnetic resonance spectroscopy techniques for the non-invasive assessment of metabolism in the rodent heart
nork: Dodd, MS
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Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.
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Myocardial substrate metabolism in obesity
nork: Rider, O, et al.
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Myocardial substrate metabolism in obesity.
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Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
nork: Schroeder, M, et al.
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In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
nork: Schroeder, M, et al.
Argitaratua: (2008)