Effect of the latent reservoir on the evolution of HIV at the within- and between- host levels

The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary dynamics of the virus has received little attention. Here, we present a within-host...

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Bibliographic Details
Main Authors: Doekes, H, Fraser, C, Lythgoe, K
Format: Journal article
Published: Public Library of Science 2017