In vivo human keyhole limpet haemocyanin challenge in early phase drug development: a systematic review

<p>Experimental exposure of healthy volunteers to the T-cell dependent neoantigen keyhole limpet hemocyanin (KLH) permits the evaluation of immunomodulatory investigational medicinal product (IMP) pharmacology prior to the recruitment of patient populations. Despite widespread use, no standard...

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Bibliographic Details
Main Authors: Drennan, PG, Karponis, K, Richards, D, Coles, M, Fullerton, J
Format: Journal article
Language:English
Published: Wiley 2022