Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lym...

Full description

Bibliographic Details
Main Authors: Ohigashi, I, Zuklys, S, Sakata, M, Mayer, C, Zhanybekova, S, Murata, S, Tanaka, K, Holländer, G, Takahama, Y
Format: Journal article
Language:English
Published: 2013