The evolutionary history of 2,658 cancers

The evolutionary history of 2,658 cancers

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 canc...

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Main Authors: Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D, Mitchell, TJ, Rubanova, Y, Anur, P, Yu, K, Tarabichi, M, Deshwar, A, Wintersinger, J, Kleinheinz, K, Vázquez-García, I, Haase, K, Jerman, L, Sengupta, S, Macintyre, G, Malikic, S, Donmez, N, Livitz, DG, Cmero, M, Demeulemeester, J, Schumacher, S, Fan, Y, Yao, X, Lee, J, Schlesner, M, Boutros, PC, Bowtell, DD, Zhu, H, Getz, G, Imielinski, M, Beroukhim, R, Sahinalp, SC, Ji, Y, Peifer, M, Markowetz, F, Mustonen, V, Yuan, K, Wang, W, Morris, QD, PCAWG Evolution & Heterogeneity Working Group, Spellman, PT, Wedge, DC, Van Loo, P, PCAWG Consortium
Format: Journal article
Sprog:English
Udgivet: Springer Nature 2020

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