Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain. Mechanisms underlying myeloma-induced bone destruction are poorly understood and current therapies do not restore lost bone mass. Using transcriptomic profiling of isola...

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Bibliographic Details
Main Authors: Gooding, S, Olechnowicz, S, Morris, E, Armitage, A, Arezes, J, Frost, J, Repapi, E, Edwards, J, Ashley, N, Waugh, C, Gray, N, Martinez-Hackert, Lim, PJ, Pasricha, S-R, Knowles, H, Mead, A, Ramasamy, K, Drakesmith, A, Edwards, C
Format: Journal article
Published: Springer Nature 2019