Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.

Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available to detect DOX-cardiotoxicity before functional decline. Mitochondrial dys...

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Bibliographic Details
Main Authors: Timm, KN, Perera, C, Ball, V, Henry, JA, Miller, JJ, Kerr, M, West, JA, Sharma, E, Broxholme, J, Logan, A, Savic, D, Dodd, MS, Griffin, JL, Murphy, MP, Heather, LC, Tyler, DJ
Format: Journal article
Language:English
Published: Springer Science and Business Media LLC 2020