Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group.

OBJECTIVES: To determine the safety, pharmacokinetics, and activity of an anti-tumor necrosis factor (TNF)-alpha monoclonal antibody in severe sepsis. DESIGN: Open-label, prospective, phase II multicenter trial with escalating doses of a murine monoclonal antibody (CB0006). SETTING: Twelve academic...

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Bibliographic Details
Main Authors:	Fisher, C, Opal, S, Dhainaut, J, Stephens, S, Zimmerman, J, Nightingale, P, Harris, S, Schein, R, Panacek, E, Vincent, J
Format:	Journal article
Language:	English
Published:	1993

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group.

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