Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group.

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group.

OBJECTIVES: To determine the safety, pharmacokinetics, and activity of an anti-tumor necrosis factor (TNF)-alpha monoclonal antibody in severe sepsis. DESIGN: Open-label, prospective, phase II multicenter trial with escalating doses of a murine monoclonal antibody (CB0006). SETTING: Twelve academic...

Full description

Bibliographic Details
Main Authors: Fisher, C, Opal, S, Dhainaut, J, Stephens, S, Zimmerman, J, Nightingale, P, Harris, S, Schein, R, Panacek, E, Vincent, J
Format: Journal article
Language:English
Published: 1993

Similar Items

Similar Items