JmjC catalysed histone H2a N -methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

JmjC catalysed histone H2a N -methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

Бусад хувилбаруудыг харуулах (1)

2-Oxoglutarate (2OG) dependent Nε-methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3 of histone H2a. Unexpectedly, the results reveal that KDM4E a...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Bonnici, J, Oueini, R, Salah, E, Johansson, C, Pires, E, Abboud, M, Dawber, RS, Tumber, A, Rabe, P, Saraç, H, Schofield, CJ, Kawamura, A
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Nature Research 2024

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