p53 ubiquitination by Mdm2: a never ending tail?
p53 function is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors harbor compromised p53 activity. In normal cells, p53 is held at low levels in a latent form and cellular stress results in the rapid stabilization of p53. Mdm2 med...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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