The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A

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• Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart
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• A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
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