Exposing viruses: RNA patterns sensed by RIG-I-like receptors.
INTRODUCTION: Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell rec...
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797060691989889024 |
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| author | Rehwinkel, J |
| author_facet | Rehwinkel, J |
| author_sort | Rehwinkel, J |
| collection | OXFORD |
| description | INTRODUCTION: Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection. SCOPE: This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses. |
| first_indexed | 2024-03-06T20:20:42Z |
| format | Journal article |
| id | oxford-uuid:2daed05b-9ecf-481c-8eeb-9800a001d6fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:20:42Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:2daed05b-9ecf-481c-8eeb-9800a001d6fe2022-03-26T12:44:31ZExposing viruses: RNA patterns sensed by RIG-I-like receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2daed05b-9ecf-481c-8eeb-9800a001d6feEnglishSymplectic Elements at Oxford2010Rehwinkel, J INTRODUCTION: Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection. SCOPE: This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses. |
| spellingShingle | Rehwinkel, J Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title | Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title_full | Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title_fullStr | Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title_full_unstemmed | Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title_short | Exposing viruses: RNA patterns sensed by RIG-I-like receptors. |
| title_sort | exposing viruses rna patterns sensed by rig i like receptors |
| work_keys_str_mv | AT rehwinkelj exposingvirusesrnapatternssensedbyrigilikereceptors |