Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis.
Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was id...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826265252757504000 |
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| author | Lim, S Gordon-Weeks, A Zhao, L Tapmeier, T Im, J Cao, Y Beech, J Allen, D Smart, S Muschel, R |
| author_facet | Lim, S Gordon-Weeks, A Zhao, L Tapmeier, T Im, J Cao, Y Beech, J Allen, D Smart, S Muschel, R |
| author_sort | Lim, S |
| collection | OXFORD |
| description | Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings. |
| first_indexed | 2024-03-06T20:20:46Z |
| format | Journal article |
| id | oxford-uuid:2db31d19-d762-4d52-a659-dd5da50abd6d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:20:46Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:2db31d19-d762-4d52-a659-dd5da50abd6d2022-03-26T12:44:41ZRecruitment of myeloid cells to the tumor microenvironment supports liver metastasis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2db31d19-d762-4d52-a659-dd5da50abd6dEnglishSymplectic Elements at Oxford2013Lim, SGordon-Weeks, AZhao, LTapmeier, TIm, JCao, YBeech, JAllen, DSmart, SMuschel, RTumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings. |
| spellingShingle | Lim, S Gordon-Weeks, A Zhao, L Tapmeier, T Im, J Cao, Y Beech, J Allen, D Smart, S Muschel, R Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title | Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title_full | Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title_fullStr | Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title_full_unstemmed | Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title_short | Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. |
| title_sort | recruitment of myeloid cells to the tumor microenvironment supports liver metastasis |
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