Cellular response to DNA interstrand crosslinks: The Fanconi Anemia pathway

Cellular response to DNA interstrand crosslinks: The Fanconi Anemia pathway

Interstrand crosslinks (ICLs) are a highly toxic form of DNA damage. ICLs can interfere with vital biological processes requiring separation of the two DNA strands, such as replication and transcription. If ICLs are left unrepaired, it can lead to mutations, chromosome breakage and mitotic catastrop...

Bibliografski detalji
Glavni autori:	Lopez-Martinez, D, Liang, C, Cohn, M
Format:	Journal article
Izdano:	Springer Verlag 2016

Slični predmeti

UHRF1 Is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi Anemia pathway
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UHRF1 is a sensor for DNA interstrand crosslinks.
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WRNIP1 is recruited to DNA interstrand crosslinks and promotes repair
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The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks prior to monoubiquitination of FANCD2
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Phosphorylation of FANCD2 inhibits the FANCD2/FANCI complex and suppresses the Fanconi anemia pathway in the absence of DNA damage
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Single Molecule Analysis of Laser Localized Interstrand Crosslinks
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RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.
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RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
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Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage
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DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
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Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway
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DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta.
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