Links between the unfolded protein response and the DNA damage response in hypoxia
Hypoxia is a common feature of solid tumours and is associated with poor patient prognosis, therapy resistance and metastasis. Severe hypoxia (<0.1% O2) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response (DDR) and the unfolded protei...
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| Format: | Thesis |
| Language: | English |
| Published: |
2022
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