A protein particle vaccine containing multiple malaria epitopes.
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826265381525782528 |
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| author | Gilbert, S Plebanski, M Harris, S Allsopp, C Thomas, R Layton, G Hill, A |
| author_facet | Gilbert, S Plebanski, M Harris, S Allsopp, C Thomas, R Layton, G Hill, A |
| author_sort | Gilbert, S |
| collection | OXFORD |
| description | Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences. |
| first_indexed | 2024-03-06T20:22:49Z |
| format | Journal article |
| id | oxford-uuid:2e6768d6-ac5f-4573-a29d-d8761c43feb1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:22:49Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:2e6768d6-ac5f-4573-a29d-d8761c43feb12022-03-26T12:48:43ZA protein particle vaccine containing multiple malaria epitopes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e6768d6-ac5f-4573-a29d-d8761c43feb1EnglishSymplectic Elements at Oxford1997Gilbert, SPlebanski, MHarris, SAllsopp, CThomas, RLayton, GHill, ATy virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences. |
| spellingShingle | Gilbert, S Plebanski, M Harris, S Allsopp, C Thomas, R Layton, G Hill, A A protein particle vaccine containing multiple malaria epitopes. |
| title | A protein particle vaccine containing multiple malaria epitopes. |
| title_full | A protein particle vaccine containing multiple malaria epitopes. |
| title_fullStr | A protein particle vaccine containing multiple malaria epitopes. |
| title_full_unstemmed | A protein particle vaccine containing multiple malaria epitopes. |
| title_short | A protein particle vaccine containing multiple malaria epitopes. |
| title_sort | protein particle vaccine containing multiple malaria epitopes |
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