Limited in vivo reactivity of polyclonal effector cytotoxic T cells towards altered peptide ligands.

T cell responses are regulated by the affinity/avidity of the T cell receptor for the MHC/peptide complex, available costimulation and duration of antigenic stimulation. Altered peptide ligands (APLs) are usually recognized with a reduced affinity/avidity by the T cell receptor and are often able to...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Bättig, P, Saudan, P, Storni, T, Gallimore, A, Bachmann, M
Materialtyp: Journal article
Språk:English
Publicerad: 2005