Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 in...

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Main Authors: Wain, L, Shrine, N, Artigas, M, Erzurumluoglu, A, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, A, Portelli, M, Hall, R, Billington, C, Rimington, T, Fenech, A, John, C, Blake, T, Jackson, V, Allen, R, Prins, B, Understanding Society Scientific Group, Campbell, A, Porteous, D, Jarvelin, M, Wielscher, M, James, A, Hui, J, Wareham, N, Zhao, J, Wilson, J, Joshi, P, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N, Karrasch, S, Gieger, C, Deary, I, Harris, S, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, O, Evans, D, Henderson, A, Pennell, C, Wang, C, Sly, P, Wan, E, Busch, R, Hobbs, B, Litonjua, A, Sparrow, D, Gulsvik, A, Bakke, P, Crapo, J, Beaty, T, Hansel, N, Mathias, R, Ruczinski, I, Barnes, K, Bossé, Y, Joubert, P, van den Berge, M, Brandsma, C, Paré, P, Sin, D, Nickle, D, Hao, K, Gottesman, O, Dewey, F, Bruse, S, Carey, D, Kirchner, H, Geisinger-Regeneron DiscovEHR Collaboration, Jonsson, S, Thorleifsson, G, Jonsdottir, I, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, E, Loos, R, Walters, R, Chen, Z, Millwood, I, Vaucher, J, Kurmi, O, Li, L, Hansell, A, Brightling, C, Zeggini, E, Cho, M, Silverman, E, Sayers, I, Trynka, G, Morris, A, Strachan, D, Hall, I, Tobin, M
Format: Journal article
Language:English
Published: Springer Nature 2017

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