γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II)-dependent oxygenase that catalyses the final step of L-carnitine biosynthesis in animals. BBOX catalyses the oxidation of 3-(2,2,2-trimethylhydrazinium)propionate (THP), a clinically used BBOX inhibitor, to form multiple products incl...

Полное описание

Библиографические подробности
Главные авторы: Henry, L, Leung, I, Claridge, T, Schofield, C
Формат: Journal article
Язык:English
Опубликовано: 2012