High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection.

BACKGROUND: Dengue is one of the most important human diseases transmitted by an arthropod vector and the incidence of dengue virus infection has been increasing - over half the world's population now live in areas at risk of infection. Most infections are asymptomatic, but a subset of patients...

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Main Authors: Dong, T, Moran, E, Vinh Chau, N, Simmons, C, Luhn, K, Peng, Y, Wills, B, Phuong Dung, N, Thi Thu Thao, L, Hien, T, McMichael, A, Farrar, J, Rowland-Jones, S
Format: Journal article
Language:English
Published: Public Library of Science 2007