Endothelial cells and peripheral blood mononuclear cells are a potential source of extraplacental activin a in preeclampsia.

An excessive systemic inflammatory response, involving endothelial cells and leukocytes, underlies the maternal symptoms of preeclampsia. Activin A is raised in preeclampsia, suggesting a possible involvement in its pathophysiology. The placenta is the main source of activin A in normal pregnancy. W...

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Bibliographic Details
Main Authors: Tannetta, D, Muttukrishna, S, Groome, N, Redman, C, Sargent, I
Format: Journal article
Language:English
Published: 2003