Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria

<p><strong>Background</strong></p> In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria. <p>&...

Full description

Bibliographic Details
Main Authors: Kingston, HWF, Ghose, A, Rungpradubvong, V, Satitthummanid, S, Herdman, MT, Plewes, K, Ishioka, H, Leopold, SJ, Sinha, I, Intharabut, B, Piera, K, McNeil, Y, Mohanty, S, Maude, RJ, White, N, Day, NPJ, Yeo, TW, Hossain, MA, Anstey, NM, Dondorp, AM
Format: Journal article
Language:English
Published: Oxford University Press 2019