Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma.

BACKGROUND: The safety and efficacy of immunotherapy with histamine dihydrochloride (HDC), interleukin-2 (IL-2) and interferon-alpha2b (IFN) compared with dacarbazine (DTIC) in adult patients with stage IV melanoma was evaluated. PATIENTS AND METHODS: Two hundred and forty-one patients were randomiz...

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Bibliographic Details
Main Authors: Middleton, M, Hauschild, A, Thomson, D, Anderson, R, Burdette-Radoux, S, Gehlsen, K, Hellstrand, K, Naredi, P
Format: Journal article
Language:English
Published: 2007