Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data

<strong>Background:</strong> The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any confounding effects of α-...

Full description

Bibliographic Details
Main Authors: Ndila, C, Nyirongo, V, Macharia, A, Jeffreys, A, Rowlands, K, Hubbart, C, Busby, G, Band, G, Harding, R, Rockett, K, Williams, TN
Other Authors: MalariaGEN Consortium
Format: Journal article
Language:English
Published: F1000Research 2021